All calming aids should be used responsibly. It is recommended that ALL calming aids are used alongside or to complement a dog behaviour modification & training plan. Do not just use the items alone, ensure you have a good training plan for them to be used as a tool alongside to enhance progress. Regarding the supplements always make sure you inform your vet of what supplements you are using to add it to their notes for reference and ensure you do not mix the supplements together. However, you can use the supplements alongside the diffusers, collars, thunder shirts and Rescue Remedy. If in doubt discuss with a qualified behaviourist, clinical animal behaviourist or your vet.